BSTA 517 Statistical Methods for Clinical Trial Design

Starting with an overview of clinical trials, the course focuses on phase I, II and III trials including most commonly used single-stage, two-stage and randomized controlled designs. The course will also cover recent advancements in trial designs and analysis considerations, design-specific sample size and power computations, and special topics such as adaptive designs, biomarker driven trials and pragmatic clinical trials. Bayesian approaches will be discussed where applicable across different design frameworks. This course will illustrate various trial designs through examples and case studies.